The size of the desalination and buffer trade market will reach USD 1,691.9 million in 2028; 10.3% CAGR – Reports and Data



The growing emphasis on proteomics and genomics research, the growing need to separate monoclonal antibodies from impurities, and the increasing application of chromatography technique in various end-use industries are key factors in the growth of the market

New York, New York – (Newsfile Corp. – April 22, 2021) – The global market size for desalting and swapping buffers is expected to reach $ 1,691.9 million in 2028 with a CAGR of 10.3%, according to the latest report from Reports and Data. Increasing investments in the biopharmaceutical industry, increasing demand and production of monoclonal antibodies, and increasing attention given to proteomics and genomics research are key factors that are expected to drive the market revenue growth over the course of the forecast period. The growing importance of the exchange of buffers in the preparation and purification of biological samples is also a key driver for the market revenue growth. Advances in molecular chemistry and increasing application of chromatography techniques in various end-use industries are other major factors which are expected to drive the market revenue growth during the forecast period.

Market Size – USD 827.05 Million in 2020, Market Growth – at 10.3% CAGR, Market Trends – Growing Application of Desalting and Buffer Exchange in Antibody Purification

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Desalting is a process that removes salts and other impurities from a sample while buffer exchange is performed to replace the buffer system used with one more suitable for specific downstream applications. Desalting and buffer exchange are mainly based on gel filtration chromatography. These methods aim to recover the components of a sample in buffer systems used to pre-equilibrate the small porous polymer beads. Desalting removes phenol or unincorporated nucleotides from nucleic acids, salts from protein solutions and excess labeling agents from conjugated proteins. The exchanged buffer replaces the old buffer system with the one suitable for downstream applications such as electrophoresis, ion exchange or affinity chromatography. Desalting and buffering exchange also aims to separate monoclonal antibodies and other biological therapeutics from impurities, which is expected to drive the market growth during the forecast period.

The increasing demand for pure monoclonal antibodies to develop effective therapeutic approaches to meet the growing unmet medical demand across the globe is expected to drive the market growth during the forecast period. In addition, the expiration of patented drugs and increasing opportunities for the production of generic drugs in developing regions are also expected to contribute to the market revenue growth during the forecast period. However, the lack of skilled professionals and the high costs associated with experiments are expected to limit the growth of the market to some extent during the forecast period.

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Some highlights of the report:

  • Sales of kits segment is expected to increase significantly during the forecast period due to increasing demand for desalination kits for protein sample preparation, increasing use of SDS-PAGE kits and of mass spectrophotometry, and the growing need to separate monoclonal antibodies from impurities.

  • Efficient ultrafiltration process is required to achieve large scale highly concentrated mAb solutions and this is expected to contribute to filtration segment revenue growth during the forecast period. In addition, minimal costs, various advantages of ultrafiltration and increasing demand for monoclonal antibodies are key factors which are expected to further fuel the revenue growth of this segment during the forecast period.

  • The bioprocess segment is expected to represent significant revenue growth during the forecast period owing to the increasing demand for biological therapeutics, the rapid development of bioprocesses and the increasing demand for efficient sample preparation and purification.

  • The revenue of the Asia-Pacific market is expected to increase significantly during the forecast period owing to the rapid expansion of the biopharmaceutical industry, the increasing penetration of clinical research organizations, and the increase in R&D in the pharmaceutical industry. biotechnology.

  • The main companies operating in the market are Thermo Fisher Scientific, Inc., Merck AG, GE Healthcare, Danaher Corporation, Sartorius, Agilent Technologies, Inc., VWR International LLC, Bio-works Technologies AB, Bio-Rad Laboratories and Norgen Biotek Corp .

  • In April 2020, Pall Corporation, which is a leading company providing filtration, separation and purification solutions, unveiled the next generation of its laboratory-scale Tangential Flow Filtration (TFF) solutions. The system, known as the Minimate EVO TFF System, is convenient to use and aims to streamline the laboratory-scale concentration, desalting and buffer exchange workflows.

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For the purpose of this report, Reports and Data has segmented the global Buffer Desalting and Exchange market on the basis of product, technique, application, and region:

Product Outlook (Revenue, USD Million; 2018-2028)

  • Kits

  • Cassettes and cartridges

  • Rotation columns

  • Other

Technical Outlook (Revenue, USD Million; 2018-2028)

  • Filtration

  • Chromatography

  • Precipitation

Application Outlook (Revenue, USD Million; 2018-2028)

  • Application of bioprocesses

  • Diagnostic application

Regional Outlook (Revenue, USD Million; 2018-2028)

  • North America

  • Europe

    • Germany

    • UK

    • Italy

    • France


    • The rest of europe

  • Asia Pacific

    • China

    • India

    • Japan

    • South Korea

    • Rest of APAC

  • Latin America

  • Middle East and Africa

    • Saudi Arabia

    • United Arab Emirates

    • South Africa

    • Rest of MEA

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